Purpose
To determine the efficacy of intensive vs moderate antihypertensive control on the outcome of type II diabetic end-organ
complications in normotensive and hypertensive populations, and to compare nisoldipine with enalapril as a first-line
antihypertensive agent in terms of the prevention and progression of complications of diabetes
References
Savage S, et al & Schrier
RW: The ABCD (Appropriate Blood pressure Control in Diabetes)
trial. Rationale and design
of a trial of hypertension control (moderate or intensive) in type II diabetes. Online J Curr Clin Trials 1993
Estacio RO, et al & Schrier
RW: The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in
patients with non-insulin-dependent diabetes and hypertension. N Engl J Med 1998, 338:645-652
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Farmacêutica