Purpose
To compare the long-term benefit/risk profiles of flecainide, propafenone and amiodarone in patients with complex ventricular
arrhythmias and heart disease and to study the effect of the drugs on heart rate variability
References
Zuanetti G, Latini R, Neilson JMM, et al: Heart rate variability in patients with ventricular arrhythmias: effect of
antiarrhythmic drugs. J Am Coll Cardiol 1991, 17:604–12.
Antiarrhythmic Drug Evaluation Group: A multicentre, randomised trial on the benefit/risk profile of amiodarone,
flecainide and propafenone in patients with cardiac disease and complex ventricular arrhythmias. Am Heart J 1992,
124:374–380.
Vincenti A, Landolina M, Latini R, et al: Washout of long-term treatment with flecainide and propafenone in patients
with complex ventricular arrhythmias and cardiac disease. Eur Heart J 1992, 13:1251–1258.
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Farmacêutica