Purpose
1. To investigate the effect of prophylactic antiarrhythmic treatment on mortality and arrhythmic events
2. To assess whether the effect of low-dose amiodarone was dependent on left ventricular (LV) function
References
Burkart F, Pfisterer M, Kiowski W, et al: Effect of antiarrhythmic therapy on mortality in survivors of myocardial
infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhythmic Study of Infarct Survival
(BASIS). J Am Coll Cardiol 1990, 16:1711–1718.
Pfisterer M, Kiowski W, Burckhardt D, et al: Beneficial effect of amiodarone on cardiac mortality in patients with
asymptomatic complex ventricular arrhythmias after acute myocardial infarction and preserved but not impaired left
ventricular function. Am J Cardiol l992, 69:1399–1402.
Kiowski W, Brunner H, Pfisterer M, et al: Langzeiteffekt der Amiodarone-Therapie nach Myokardinfarkt bei komplexen
ventrikulären Rhythmusstörungen (Long-term effect of amiodarone therapy after myocardial infarction in patients
with complex ventricular arrhythmias. Schweiz Med Wochenschr 1993, 123:533–536.
Pfisterer M, Kiowski W, Brunner H, et al: Long-term benefit of 1-year amiodarone treatment for persistent complex
ventricular arrhythmias after myocardial infarction. Circulation 1993, 87:309–311.
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Farmacêutica