Purpose
To investigate the effect of enalapril, in addition to conventional therapy, on mortality in severe CHF. To study the activation of
hormones related to cardiovascular function and the effect of the overall hormone response to angiotensin converting enzyme
(ACE) inhibition.
References
The Consensus trial study group: Effects of enalapril on mortality in severe congestive heart failure; results of the
Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987, 316:1429–1435
.Swedberg K, Eneroth P, Kjekshus J, et al: Hormones regulating cardiovascular function in patients with severe
congestive heart failure and their relation to mortality. Circulation 1990, 82:1730–1736.
Swedberg K, Eneroth P, Kjekshus J, et al: Effects of enalapril and neuroendocrine activation on prognosis in severe
congestive heart failure (follow-up of the CONSENSUS trial). Am J Cardiol 1990, 66:40D–45D.
Kjekshus J, Swedberg K, Snapinn S: Effects of enalapril on long-term mortality in severe congestive heart failure. Am J
Cardiol 1992, 69:103–107.
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Farmacêutica